The FP420 R&D Project at the LHC

A brief review of the FP420 R&D project at the LHC is presentedA brief review of the FP420 R&D project at the LHC is presente

High-t Diffraction at HERA

The double dissociation photoproduction cross section for the process gamma p -> XY, in which the systems X and Y are separated by a large rapidity gap, is measured at large 4-momentum transfer squared |t| > 20 GeV^2 by the H1 Collaboration at HERA. This measurement provides for the first time a direct measurement of the energy dependence of the gap production process at high |t|.Comment: 3 pages, 2 figures, Talk presented at DIS99, Zeuthen, German

WW scattering at the CERN LHC

A detailed study is presented of elastic WW scattering in the scenario that there are no new particles discovered prior to the commissioning of the CERN LHC. We work within the framework of the electroweak chiral Lagrangian and two different unitarization protocols are investigated. Signals and backgrounds are simulated to the final-state-particle level. A new technique for identifying the hadronically decaying W is developed, which is more generally applicable to massive particles which decay to jets where the separation of the jets is small. The effect of different assumptions about the underlying event is also studied. We conclude that the channel WW-->jj+lν may contain scalar and/or vector resonances which could be measurable after 100 fb-1 of LHC data

Double Diffraction Dissociation at High t

Diffractive scattering in the presence of a large momentum transfer is an ideal place to study the short distance rapidity gap producing mechanism. Previous studies (experimental and theoretical) in this area have focussed on gaps between jets and on high-$t$ vector meson production. We propose the measurement of double dissociation at high-$t$. We examine the numerous advantages to studying this more inclusive process and conclude that it is an ideal place to study short distance diffraction.Comment: 12 pages, 8 figure

Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators

Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value, increasing phagocytosis and reducing sepsis-induced lethality. Here we identify for the first time the bacterial targets of Ru(CO)(3)Cl(glycinate) (CORM-3), a ruthenium-based carbonyl that liberates CO rapidly under physiological conditions. Contrary to the expectation that CO would be preferentially inhibitory at low oxygen tensions or anaerobically, Escherichia coli cultures were also sensitive to CORM-3 at concentrations equimolar with oxygen. CORM-3, assayed as ruthenium, was taken up by bacteria and rapidly delivered CO intracellularly to terminal oxidases. Microarray analysis of CORM-3-treated cells revealed extensively modified gene expression, notably down-regulation of genes encoding key aerobic respiratory complexes. Genes involved in metal metabolism, homeostasis, or transport were also differentially expressed, and free intracellular zinc levels were elevated. Probabilistic modeling of transcriptomic data identified the global transcription regulators ArcA, CRP, Fis, FNR, Fur, BaeR, CpxR, and IHF as targets and potential CO sensors. Our discovery that CORM-3 is an effective inhibitor and global regulator of gene expression, especially under aerobic conditions, has important implications for administration of CO-releasing agents in sepsis and inflammatio

Site-Specific Iron Substitution in STA-28, a Large Pore Aluminophosphate Zeotype Prepared by Using 1, 10-Phenanthrolines as Framework-Bound Templates

An AlPO4 zeotype has been prepared using the aromatic diamine 1, 10-phenanthroline and some of its methylated analogues as templates. In each case the two template N atoms bind to a specific framework Al site to expand its coordination to the unusual octahedral AlO4N2 environment. Furthermore, using this framework-bound template, Fe atoms can be included selectively at this site in the framework by direct synthesis, as confirmed by annular dark field scanning transmission electron microscopy and Rietveld refinement. Calcination removes the organic molecules to give large pore framework solids, with BET surface areas up to 540 m2 g-1 and two perpendicular sets of channels that intersect to give pore space connected by 12-ring openings along all crystallographic directions

High resolution 3D ultrasonic breast imaging by time-domain full waveform inversion

Ultrasound tomography (UST) scanners allow quantitative images of the human breast's acoustic properties to be derived with potential applications in screening, diagnosis and therapy planning. Time domain full waveform inversion (TD-FWI) is a promising UST image formation technique that fits the parameter fields of a wave physics model by gradient-based optimization. For high resolution 3D UST, it holds three key challenges: firstly, its central building block, the computation of the gradient for a single US measurement, has a restrictively large memory footprint. Secondly, this building block needs to be computed for each of the 1000 to 10000 measurements, resulting in a massive parallel computation usually performed on large computational clusters for days. Lastly, the structure of the underlying optimization problem may result in slow progression of the solver and convergence to a local minimum. In this work, we design and evaluate a comprehensive computational strategy to overcome these challenges: firstly, we exploit a gradient computation based on time reversal that dramatically reduces the memory footprint at the expense of one additional wave simulation per source. Secondly, we break the dependence on the number of measurements by using source encoding (SE) to compute stochastic gradient estimates. Also we describe a more accurate, TD-specific SE technique with a finer variance control and use a state-of-the-art stochastic LBFGS method. Lastly, we design an efficient TD multi-grid scheme together with preconditioning to speed up the convergence while avoiding local minima. All components are evaluated in extensive numerical proof-of-concept studies simulating a bowl-shaped 3D UST breast scanner prototype. Finally, we demonstrate that their combination allows us to obtain an accurate 442 × 442 × 222 voxel image with a resolution of 0.5 mm using Matlab on a single GPU within 24 h

Diffractive upsilon production at the LHC

We compute the rate for diffractive upsilon meson production at the Tevatron and the LHC. The upsilon is produced diffractively via the subprocess gamma + p -> upsilon + p where the initial photon is radiated off an incoming proton (or antiproton). We consider the possibility to use low angle proton detectors to make a measurement of the gamma p cross-section and conclude that a measurement of the cross-section at a centre of mass energy in excess of 1 TeV is possible at the LHC. This is in the region where saturation effects are likely to reveal themselves.Comment: 14 page

The Local Bubble and Interstellar Material Near the Sun

The properties of interstellar matter (ISM) at the Sun are regulated by our location with respect to the Local Bubble (LB) void in the ISM. The LB is bounded by associations of massive stars and fossil supernovae that have disrupted natal ISM and driven intermediate velocity ISM into the LB interior void. The Sun is located in such a driven ISM parcel. The Local Fluff has a bulk velocity of 19 km/s in the LSR, and an upwind direction towards the center of the gas and dust ring formed by the Loop I supernova remnant interaction with the LB. When the ram pressure of the LIC is included in the total LIC pressure, and if magnetic thermal and cosmic ray pressures are similar, the LIC appears to be in pressure equilibrium with the local hot bubble plasma.Comment: Proceedings of Symposium on the Composition of Matter, honoring Johannes Geiss on the occasion of his 80th birthday. Space Science Reviews (in press